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Stroke is a leading cause of disability and death globally, making timely and effective treatment crucial for enhancing patient outcomes. Evidence-based nursing practice (EBNP) plays a vital role in stroke management by integrating the best available research, clinical expertise, and patient preferences to optimize care. This paper examines key evidence-based practices in the nursing care of stroke patients, including early stroke identification, prompt administration of thrombolytic therapy, acute care management, strategies for secondary prevention, and post-stroke rehabilitation. Nurses are essential in monitoring vital signs, assessing neurological function, managing blood pressure and glucose levels, and preventing complications such as deep vein thrombosis and pneumonia. Research supports the effectiveness of administering thrombolytic therapy within 3 to 4.5 hours of symptom onset, as well as the use of antiplatelet therapy, blood pressure control, and statins in preventing recurrent strokes. Rehabilitation, encompassing physical and speech therapy, along with psychosocial support, is critical for improving functional recovery and quality of life. Moreover, patient and family education is fundamental for long-term stroke prevention and management. By implementing evidence-based strategies, nurses significantly contribute to reducing morbidity and mortality, enhancing recovery, and improving the overall quality of life for stroke survivors.